QTc interval analysis—an ever-evolving endeavor
نویسندگان
چکیده
منابع مشابه
Ketamine-induced QTc interval prolongation
Sir, Ketamine is a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor. It is widely used as a dissociative anesthetic and is also used as an adjunct in pain management, particularly in opioid-tolerant patients. It blocks calcium channels and depresses sodium channel function as well as having anticholinergic effects. It inhibits the re-uptake of the catecholamines and may hav...
متن کاملDRUGS AND QTc INTERVAL DISPERSION
The measure of delayed ventricular repolarization most frequently used clinically is the ability of the new chemical entity to prolong the QTc interval on surface electrocardiogram. Intramyocardial dispersion of repolarization appears to play a more important role both in electrical stability of the ventricles and in arrhythmogenesis. The potential importance of myocardial dispersion of refract...
متن کاملInsulin prolongs the QTc interval in humans.
Insulin hyperpolarizes plasma membranes; we tested whether insulin affects ventricular repolarization. In 35 healthy volunteers, we measured the Q-T interval during electrocardiographic monitoring in the resting state and in response to hyperinsulinemia (euglycemic 1-mU. min(-1). kg(-1) insulin clamp). A computerized algorithm was used to identify T waves; Bazett's formula was employed to corre...
متن کاملQTc interval screening in methadone treatment.
DESCRIPTION An independent panel developed cardiac safety recommendations for physicians prescribing methadone. METHODS Expert panel members reviewed and discussed the following sources regarding methadone: pertinent English-language literature identified from MEDLINE and EMBASE searches (1966 to June 2008), national substance abuse guidelines from the United States and other countries, infor...
متن کاملGuEst Editorial PrEfacE Open Source Software Research: An Evolving Endeavor
i The purpose of this special issue is to provide a rigorous examination of the open source software (OSS) movement, with special consideration to the impact it has on not only the software products, but also the software industry as a whole. Naturally, the OSS movement is large and has many facets that could be worthwhile to investigate. For this special issue, we tried to take as open an appr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Pharmacokinetics and Pharmacodynamics
سال: 2021
ISSN: 1567-567X,1573-8744
DOI: 10.1007/s10928-021-09754-z